Shopping Cart
- Remove All
![TargetMol](https://www.targetmol.com/storage/error/oops.webp)
Your shopping cart is currently empty
Pack Size | Price | Availability | Quantity |
---|---|---|---|
500 μg | $275 | 35 days | |
1 mg | $488 | 35 days | |
5 mg | $1,890 | 35 days | |
10 mg | $2,700 | 35 days |
Description | MIV-150 is a nonnucleoside inhibitor of reverse transcriptase (NNRT). MIV-150 also blocking HIV-1 and HIV-2 infections (EC50<1 nM against HIV-1/HIV-2MN). |
Targets&IC50 | HIV-2:<1 nM (EC50), HIV-1:<1 nM (EC50) |
In vitro | MIV-150 demonstrates potent antiviral efficacy by inactivating free HIV virus with an EC50 of 0.004 μg/mL (or 0.01 μM), showcasing its high effectiveness against HIV, including strains resistant to other marketed antiretrovirals like Nevirapine, Delavirdine, and Efavirenz. Remarkably, resistance to MIV-150 develops slower compared to other anti-HIV drugs, as evident from in vitro studies where resistance to Nevirapine and Delavirdine emerged within 4 to 5 weeks, whereas resistance to MIV-150 took up to 45 weeks. Additionally, MIV-150's ability to protect target cells from infection was demonstrated through a syncytial assay, revealing an EC50 against HIV-1MN in CEM.SS cells below 1 nM, aligning with Medivir's findings. |
Alias | PC 815 |
Molecular Weight | 368.36 |
Formula | C19H17FN4O3 |
Cas No. | 231957-54-3 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.