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Mivotilate
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Catalog No. T16082Cas No. 130112-42-4
Alias YH439
Mivotilate, a potent, non-toxic aryl hydrocarbon receptor (AhR) activator, functions as a hepatoprotective agent.
Mivotilate
😃Good
Catalog No. T16082Alias YH439Cas No. 130112-42-4
Mivotilate, a potent, non-toxic aryl hydrocarbon receptor (AhR) activator, functions as a hepatoprotective agent.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $916 | 6-8 weeks | |
| 50 mg | $1,190 | 6-8 weeks | |
| 100 mg | $1,860 | 6-8 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Mivotilate, a potent, non-toxic aryl hydrocarbon receptor (AhR) activator, functions as a hepatoprotective agent. |
| In vitro | Mivotilate has a novel activation mode that tolerates mutation of histidine 285 to tyrosine[1]. Mivotilate is a nontoxic and potent activator of the aryl hydrocarbon receptor. Mivotilate causes cytochromes P4501A1/2 (CYP1A1/2) through the aryl hydrocarbon (Ah) receptor[3]. |
| In vivo | Mivotilate (150 mg/kg, p.o.) inhibits the transcription of CYP2E1 in rats, and at doses of 75-300 mg/kg, it rapidly decreases immunoreactive CYP2E1 protein. Additionally, Mivotilate (150 mg/kg, p.o.) reduces CYP2E1-mediated NDMA demethylase activity in rats without significantly affecting NADPH-dependent P450 oxidoreductase activity [2]. |
| Alias | YH439 |
| Molecular Weight | 330.45 |
| Formula | C12H14N2O3S3 |
| Cas No. | 130112-42-4 |
| Relative Density. | 1.467g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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