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MK-0343
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Catalog No. T16084Cas No. 233275-76-8
Alias MRK-409
MK0343 is an orally bioavailable GABAA receptor subtype-selective partial agonist and is a non-sedating anxiolytic.
MK-0343
😃Good
Catalog No. T16084Alias MRK-409Cas No. 233275-76-8
MK0343 is an orally bioavailable GABAA receptor subtype-selective partial agonist and is a non-sedating anxiolytic.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | 186 € | 5 days | |
| 25 mg | 1.045 € | 6-8 weeks | |
| 50 mg | 1.368 € | 6-8 weeks | |
| 100 mg | 2.071 € | 6-8 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | MK0343 is an orally bioavailable GABAA receptor subtype-selective partial agonist and is a non-sedating anxiolytic. |
| Targets&IC50 | GABAA α3 (rat): 0.21 nM(ki), GABAA α5 (rat):0.23 nM(ki), GABAA α2 (rat):0.4 nM(ki), GABAA α6 (rat):980 nM(ki), GABAA α4 (rat):78 nM(ki), GABAA α1 (rat):(ki)0.22 nM |
| In vivo | MK0343 efficiently penetrates the rat brain, occupying the benzodiazepine site of GABAA receptors, as measured by an in vivo [3H]flumazenil binding assay. Its Occ50 is 2.2 mg/kg p.o., with a corresponding plasma EC50 of 115 ng/mL. |
| Alias | MRK-409 |
| Molecular Weight | 397.38 |
| Formula | C19H17F2N7O |
| Cas No. | 233275-76-8 |
| Relative Density. | 1.57 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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