Shopping Cart

Remove All
Your shopping cart is currently empty

ML314

Name: ML314
Brand: TargetMol
SKU: TQ0075
Price: 95 EUR
Availability: InStock
Rating: 4.5 (1 reviews)

Catalog No. TQ0075Cas No. 1448895-09-7

ML314 is a brain-permeable nonpeptide β-inhibin-biased neurotensin NTR1 receptor agonist (EC50: 1.9 μM), a biased neurotensin receptor ligand for methamphetamine abuse that inhibits NTR2 and GPR35.

ML314

Purity: 99.52%

Catalog No. TQ0075Cas No. 1448895-09-7

ML314 is a brain-permeable nonpeptide β-inhibin-biased neurotensin NTR1 receptor agonist (EC50: 1.9 μM), a biased neurotensin receptor ligand for methamphetamine abuse that inhibits NTR2 and GPR35.

Product information is being updated, if you want to purchase, please click the bulk custom button.

Bulk & Custom

Questions

Select Batch

Purity:99.52%

Resource Download

COA LCMS

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity

Description	ML314 is a brain-permeable nonpeptide β-inhibin-biased neurotensin NTR1 receptor agonist (EC50: 1.9 μM), a biased neurotensin receptor ligand for methamphetamine abuse that inhibits NTR2 and GPR35.
Targets&IC50	NTR1:1.9 μM (EC50)
In vitro	ML314 exhibits good solubility and high permeability in vitro, binds highly to plasma proteins, and demonstrates extremely high plasma stability[2].

Chemical Properties

Molecular Weight	420.504
Formula	C₂₄H₂₈N₄O₃
Cas No.	1448895-09-7

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 30 mg/mL (71.34 mM), Sonification is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3781 mL	11.8905 mL	23.7810 mL	118.9049 mL
5 mM	0.4756 mL	2.3781 mL	4.7562 mL	23.7810 mL
10 mM	0.2378 mL	1.1890 mL	2.3781 mL	11.8905 mL
20 mM	0.1189 mL	0.5945 mL	1.1890 mL	5.9452 mL
50 mM	0.0476 mL	0.2378 mL	0.4756 mL	2.3781 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc