MMV009085 is a potent inhibitor of the Plasmodium falciparum hexose transporter (Pf HT1), with potential as an anti-malarial agent. It also inhibits the human glucose transporter, demonstrating high potency with an IC50 of 2.6 μM in glucose uptake assays and an EC50 of 1.23±0.04 μM against the 3D7 strain of the malaria parasite [1].

MMV009085 exhibits an inhibitory effect on PfHT-1 transport activity with an IC50 value of 212±39 μM and suppresses the growth of 3D7 and Dd2 strains with EC50 values of 1.23±0.04 μM and 0.720±0.05 μM, respectively. MMV009085's cytotoxicity in HEK293T and HepG2 cells is demonstrated by CC50 values of 2.46±0.03 μM and 1.92±0.85 μM, respectively [1]. Additionally, in glucose uptake assays with free parasites, MMV009085 shows an IC50 of 2.6 μM. In vitro, it inhibits the growth of the malaria parasite 3D7 with an EC50 of 0.987 μM and impedes parasite growth through PfHT blockade (EC50 = 0.795 μM) [1].