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Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $1,520 | 10-14 weeks | |
50 mg | $1,980 | 10-14 weeks | |
100 mg | $2,500 | 10-14 weeks |
Description | Monoamine Oxidase B inhibitor 1 is a potent, reversible, orally active, and selective monoamine oxidase B (MAO-B) inhibitor (IC50 = 0.02 nM) capable of crossing the blood-brain barrier (BBB). It exhibits antioxidant and anti-neuroinflammatory activities and can be used in the study of Parkinson's disease[1]. |
In vitro | In cellular assays, the Monoamine Oxidase B inhibitor 1 (compound 14a; 0.5-10.0 μM) was shown to markedly reduce the levels of NO and TNF-α in LPS-induced BV-2 cells [1]. |
In vivo | In both acute and subacute MPTP-induced Parkinson’s disease mouse models, Monoamine Oxidase B Inhibitor 1 (compound 14a; 6-37.4 mg/kg; orally administered) significantly ameliorated most behavioral disorders, restored dopamine levels and reduced MDA levels in the striatum of mice [1]. |
Molecular Weight | 298.31 |
Formula | C18H15FO3 |
Cas No. |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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