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Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $1,520 | 10-14 weeks | |
50 mg | $1,980 | 10-14 weeks | |
100 mg | $2,500 | 10-14 weeks |
Description | Monoamine Oxidase B inhibitor 2 is a potent, reversible, orally active, and selective inhibitor of monoamine oxidase B (MAO-B) with an IC50 of 1.33 nM, capable of crossing the blood-brain barrier (BBB). It exhibits antioxidant and anti-neuroinflammatory activities and is useful in the study of Parkinson’s disease [1]. |
In vitro | In cellular assays, Monoamine Oxidase B Inhibitor 2 (compound 8f; concentration range: 0.5-10.0 μM) markedly reduced the levels of NO and TNF-α in LPS-induced BV-2 cells [1]. |
In vivo | In an in vivo acute and subacute MPTP-induced mouse model of Parkinson’s disease, Monoamine Oxidase B inhibitor 2 (compound 8f; 6.3-39.5 mg/kg; orally administered) significantly ameliorated most behavioral disorders, restored dopamine levels, and reduced MDA content in the striatum of mice [1]. |
Molecular Weight | 314.35 |
Formula | C19H19FO3 |
Cas No. |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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