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SARS-CoV MPro-IN-1

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Catalog No. T37174Cas No. 2413716-71-7

MProinhibitor 11b is an inhibitor of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (MPro; IC50= 0.04 μM in a TR-FRET assay).1It reduces viral yield in the culture supernatant of SARS-CoV-2-infected Vero E6 cells (EC50= 0.72 μM). MProinhibitor 11b also reduces viral RNA copy numbers in the same model when used at concentrations ranging from 1.85 to 50 μM.

SARS-CoV MPro-IN-1

SARS-CoV MPro-IN-1

😃Good
Catalog No. T37174Cas No. 2413716-71-7
MProinhibitor 11b is an inhibitor of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (MPro; IC50= 0.04 μM in a TR-FRET assay).1It reduces viral yield in the culture supernatant of SARS-CoV-2-infected Vero E6 cells (EC50= 0.72 μM). MProinhibitor 11b also reduces viral RNA copy numbers in the same model when used at concentrations ranging from 1.85 to 50 μM.
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1 mg$198 35 days
10 mg$1,680 35 days
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Product Introduction

Bioactivity
Description
MProinhibitor 11b is an inhibitor of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (MPro; IC50= 0.04 μM in a TR-FRET assay).1It reduces viral yield in the culture supernatant of SARS-CoV-2-infected Vero E6 cells (EC50= 0.72 μM). MProinhibitor 11b also reduces viral RNA copy numbers in the same model when used at concentrations ranging from 1.85 to 50 μM.
1.Dai, W., Zhang, B., Jiang, X.-M., et al.Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main proteaseScience368(6497)1331-1335(2020)
Chemical Properties
Molecular Weight464.49
FormulaC25H25FN4O4
Cas No.2413716-71-7
Relative Density.1.323 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 30 mg/mL (64.59 mM), Sonication is recommended.
DMF: 30 mg/mL (64.59 mM), Sonication is recommended.
Ethanol: 30 mg/mL (64.59 mM), Sonication is recommended.
Solution Preparation Table
DMSO/DMF/Ethanol
1mg5mg10mg50mg
1 mM2.1529 mL10.7645 mL21.5290 mL107.6449 mL
5 mM0.4306 mL2.1529 mL4.3058 mL21.5290 mL
10 mM0.2153 mL1.0764 mL2.1529 mL10.7645 mL
20 mM0.1076 mL0.5382 mL1.0764 mL5.3822 mL
50 mM0.0431 mL0.2153 mL0.4306 mL2.1529 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
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2 Enter the in vivo formulation:
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Keywords

SARS-CoV MPro-IN-1SARSCoV MProIN1SARS CoV MPro IN 1
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