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Mps1-IN-1

Name: Mps1-IN-1
Brand: TargetMol
SKU: T12102
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T12102Cas No. 1125593-20-5

Mps1-IN-1 is a potent, selective, and ATP-competitive inhibitor of Mps1 kinase (IC50: 367 nM).

Mps1-IN-1

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Purity: 97.78%

Catalog No. T12102Cas No. 1125593-20-5

Mps1-IN-1 is a potent, selective, and ATP-competitive inhibitor of Mps1 kinase (IC50: 367 nM).

Pack Size	Price	Availability
1 mg	$39	In Stock
5 mg	$90	In Stock
10 mg	$169	In Stock
25 mg	$333	In Stock
50 mg	$498	In Stock
100 mg	$723	In Stock
1 mL x 10 mM (in DMSO)	$107	In Stock

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Purity:97.78%

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COA HNMR HPLC LCMS

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Product Introduction

Bioactivity

Description	Mps1-IN-1 is a potent, selective, and ATP-competitive inhibitor of Mps1 kinase (IC50: 367 nM).
Targets&IC50	ALK:21 nM (kd), INSR:470 nM (kd), IGF-1R:750 nM (kd), CLK1:1900 nM (kd), FAK:440 nM (kd), PYK2:280 nM (kd), TYK1/LTK:29 nM (kd), ERK2:2900 nM (kd), TNK1:2600 nM (kd), GAK:1100 nM (kd), Mps1:27 nM (kd), INSRR:1200 nM (kd), TNK2:3100 nM (kd)
In vitro	Mps1-IN-1 is a potent, selective, and ATP-competitive inhibitor of Mps1 kinase with IC50 and Kd values of 367 nM and 27 nM, respectively. It also exhibits high affinity for ALK and LTK, with Kd values of 21 nM and 39 nM, respectively[1].

Chemical Properties

Molecular Weight	535.66
Formula	C₂₈H₃₃N₅O₄S
Cas No.	1125593-20-5
Smiles	COc1cc(ccc1Nc1cc(Nc2ccccc2S(=O)(=O)C(C)C)c2cc[nH]c2n1)N1CCC(O)CC1
Relative Density.	1.354 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 39 mg/mL (72.81 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8669 mL	9.3343 mL	18.6686 mL	93.3428 mL
5 mM	0.3734 mL	1.8669 mL	3.7337 mL	18.6686 mL
10 mM	0.1867 mL	0.9334 mL	1.8669 mL	9.3343 mL
20 mM	0.0933 mL	0.4667 mL	0.9334 mL	4.6671 mL
50 mM	0.0373 mL	0.1867 mL	0.3734 mL	1.8669 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

TNK2TNK1PYK2Mps1-IN-1Mps-1-IN-1Mps1IN1Mps1 IN 1Mps1LTKINSRRINSRIGF1RGAKFAKERK2CLK1ALK