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MRIA9
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Catalog No. T36891Cas No. 2750707-05-0
MRIA9, an ATP-competitive inhibitor targeting pan Salt-Inducible Kinases (SIK) and PAK2/3, demonstrates IC50 values of 516 nM, 180 nM, and 127 nM for SIK1, SIK2, and SIK3, respectively [1].
MRIA9
😃Good
Catalog No. T36891Cas No. 2750707-05-0
MRIA9, an ATP-competitive inhibitor targeting pan Salt-Inducible Kinases (SIK) and PAK2/3, demonstrates IC50 values of 516 nM, 180 nM, and 127 nM for SIK1, SIK2, and SIK3, respectively [1].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $598 | Backorder | |
| 10 mg | $954 | Backorder |
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Bioactivity
Chemical Properties
| Description | MRIA9, an ATP-competitive inhibitor targeting pan Salt-Inducible Kinases (SIK) and PAK2/3, demonstrates IC50 values of 516 nM, 180 nM, and 127 nM for SIK1, SIK2, and SIK3, respectively [1]. |
| In vitro | MRIA9 (5 μM) enhances sensitivity to paclitaxel in SKOV3 cells by inducing pronounced apoptosis[1]. In combination with paclitaxel (2 nM), MRIA9 significantly increases cell death in HeLa cells[1]. MRIA9 strongly impedes centrosome function, mispositions mitotic spindles in ovarian cancer cell lines, prevents centrosome disjunction during the late G2 phase, and sensitizes ovarian cancer cells and patient-derived 3D-spheroids to paclitaxel[2]. |
| In vivo | MRIA9 exhibits high oral bioavailability (F = 75-80%)[1]. |
| Molecular Weight | 496.92 |
| Formula | C24H22ClFN6O3 |
| Cas No. | 2750707-05-0 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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