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MRT00033659 is an effective broad-spectrum kinase inhibitor of CK1 (IC50=0.9 μM for CK1δ) and CHK1 (IC50=0.23 μM). MRT00033659 is a pyrazolo-pyridine analogue. It also induces p53 pathway activation and E2F-1 destabilization.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
2 mg | $68 | 5 days | |
5 mg | $128 | 5 days |
Description | MRT00033659 is an effective broad-spectrum kinase inhibitor of CK1 (IC50=0.9 µM for CK1δ) and CHK1 (IC50=0.23 µM). MRT00033659 is a pyrazolo-pyridine analogue. It also induces p53 pathway activation and E2F-1 destabilization. |
Targets&IC50 | CKIδ:0.9 μM, Chk1:0.23 μM |
In vitro | MRT00033659 does not inhibit p38α MAPK. MRT00033659 (1-80 μM; 48 hours) causes substantial cell death from 5 μM. MRT00033659 (0.2-80 μM; 48 hours) induces a robust and sustained stabilisation of p53, MDM2, and p21 proteins, as well as E2F-1 destabilisation from 0.2 μM to 5 μM. MRT00033659 (5-40 μM; 48 hours) is sufficient to obviously decrease cell number of 5 μM . |
Molecular Weight | 266.3 |
Formula | C15H14N4O |
Cas No. | 1401731-54-1 |
Relative Density. | 1.312 g/cm3 (Predicted) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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