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Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $19,800 | 8-10 weeks | |
50 mg | $26,400 | 8-10 weeks | |
100 mg | $41,800 | 8-10 weeks |
Description | MSI-1436 is a selective, non-competitive the enzyme protein-tyrosine phosphatase 1B (PTB1B)inhibitor(IC50 of appr 1 μM) |
In vitro | Trodusquemine significantly enhanced insulin-stimulated tyrosine phosphorylation of insulin receptor (IR) beta and STAT3, direct targets of PTP1B, in HepG2 cells in vitro and/or hypothalamic tissue[1]. |
In vivo | Trodusquemine (MSI-1436) causes rapid and reversible weight loss in genetic models of obesity.?Trodusquemine suppressed appetite, reduced body weight (BW) in a fat-specific manner, and improved plasma insulin and leptin levels in mice[1]. |
Alias | Aminosterol-1436, Trodusquemine |
Molecular Weight | 685.06 |
Formula | C37H72N4O5S |
Cas No. | 186139-09-3 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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