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MSI-1436 lactate

Catalog No. T12117Cas No. 1309370-86-2

MSI-1436 lactate is a selective, non-competitive the enzyme protein-tyrosine phosphatase 1B (PTB1B)inhibitor(IC50 of appr 1 μM)

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Pack Size	Price	Availability	Quantity
5 mg	$946	Backorder
10 mg	$1,590	Backorder

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Questions

Product Introduction

Bioactivity

Description	MSI-1436 lactate is a selective, non-competitive the enzyme protein-tyrosine phosphatase 1B (PTB1B)inhibitor(IC50 of appr 1 μM)
In vitro	Trodusquemine significantly enhanced insulin-stimulated tyrosine phosphorylation of insulin receptor (IR) beta and STAT3, direct targets of PTP1B, in HepG2 cells in vitro and/or hypothalamic tissue[1].
In vivo	Trodusquemine (MSI-1436) causes rapid and reversible weight loss in genetic models of obesity.?Trodusquemine suppressed appetite, reduced body weight (BW) in a fat-specific manner, and improved plasma insulin and leptin levels in mice[1].
Alias	Trodusquemine lactate, Aminosterol-1436 lactate

Chemical Properties

Molecular Weight	1000.17
Formula	C37H72N4O5S.7/2C3H6O3
Cas No.	1309370-86-2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 33.33 mg/mL (33.32 mM)

DMSO: 54 mg/mL (53.99 mM)

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	0.9998 mL	4.9992 mL	9.9983 mL	49.9915 mL
5 mM	0.2000 mL	0.9998 mL	1.9997 mL	9.9983 mL
10 mM	0.1000 mL	0.4999 mL	0.9998 mL	4.9992 mL
20 mM	0.0500 mL	0.2500 mL	0.4999 mL	2.4996 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0200 mL	0.1000 mL	0.2000 mL	0.9998 mL
100 mM	0.0100 mL	0.0500 mL	0.1000 mL	0.4999 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

MSI1436 lactateMSI 1436 lactateMSI-1436 LactateMSI1436 LactateAminosterol-1436 LactateMSI 1436 LactateTrodusquemine Lactate