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Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | Inquiry | Backorder | |
50 mg | Inquiry | Backorder |
Description | Multi-kinase-IN-5 (compound 15c) is a multi-kinase inhibitory agent that shows significant inhibition against a range of protein kinases including RET, KIT, cMet, VEGFR1, VEGFR2, FGFR1, PDGFR, and BRAF, with corresponding inhibition percentages of 74%, 31%, 62%, 40%, 73%, 74%, 59%, and 69%. Its IC50 values are 1.287 μM for FGFR1, 0.117 μM for VEGFR, and 1.185 μM for RET kinases, indicating its potency [1]. |
In vitro | Multi-kinase-IN-5 (compound 15c) demonstrated robust antiproliferative activity against the majority of cell lines in the National Cancer Institute's (NCI) 60 cell line panel, with an average growth inhibition rate of 61.83%. It achieved IC50 values of 4.39, 1.06, and 0.34 nM against the MCT-7, DU 145, and HCT-116 cell lines, respectively [1]. |
Molecular Weight | 377.42 |
Formula | C19H15N5O2S |
Cas No. |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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