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Multi-kinase-IN-5

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Catalog No. T77646

Multi-kinase-IN-5 (compound 15c) is a multi-kinase inhibitory agent that demonstrates significant inhibition of a range of protein kinases, including RET (69%), KIT (31%), cMet (62%), VEGFR1 (40%), VEGFR2 (73%), FGFR1 (74%), PDGFR (59%), and BRAF (74%). Its IC50 values are 1.287 μM for FGFR1, 0.117 μM for VEGFR, and 1.185 μM for RET kinases, indicating its potency [1].

Multi-kinase-IN-5

Multi-kinase-IN-5

😃Good
Catalog No. T77646
Multi-kinase-IN-5 (compound 15c) is a multi-kinase inhibitory agent that demonstrates significant inhibition of a range of protein kinases, including RET (69%), KIT (31%), cMet (62%), VEGFR1 (40%), VEGFR2 (73%), FGFR1 (74%), PDGFR (59%), and BRAF (74%). Its IC50 values are 1.287 μM for FGFR1, 0.117 μM for VEGFR, and 1.185 μM for RET kinases, indicating its potency [1].
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Product Introduction

Bioactivity
Description
Multi-kinase-IN-5 (compound 15c) is a multi-kinase inhibitory agent that demonstrates significant inhibition of a range of protein kinases, including RET (69%), KIT (31%), cMet (62%), VEGFR1 (40%), VEGFR2 (73%), FGFR1 (74%), PDGFR (59%), and BRAF (74%). Its IC50 values are 1.287 μM for FGFR1, 0.117 μM for VEGFR, and 1.185 μM for RET kinases, indicating its potency [1].
Targets&IC50
FGFR1:1.287 μM
In vitro
Multi-kinase-IN-5 (compound 15c) exhibited potent antiproliferative activity against most cell lines in the National Cancer Institute's (NCI) 60 cell line panel, with an average growth inhibition rate of 61.83%. It achieved IC50 values of 4.39, 1.06, and 0.34 nM against the MCT-7, DU 145, and HCT-116 cell lines, respectively [1].
Chemical Properties
Molecular Weight377.42
FormulaC19H15N5O2S
Storage & Solubility Information
StorageShipping with blue ice.

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Keywords

MultikinaseIN5
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