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Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $970 | Backorder |
Description | Multitarget AD inhibitor-1 is a reversible and selective inhibitor of butyrylcholinesterase (BuChE) with IC50 values of 7.22 μM for human BuChE (hBuChE) and 1.55 μM for equine serum BuChE (eqBuChE). It also exhibits inhibitory activity towards β-secretase (IC50 41.60 μM), amyloid β aggregation (IC50 3.09 μM), and tau aggregation. As a diphenylpropylamine derivative, Multitarget AD inhibitor-1 is promising for research into multifunctional, disease-modifying treatments for Alzheimer's disease. |
In vitro | Multitarget Alzheimer's Disease (AD) inhibitor-1 (compound 10) selectively inhibits both equine serum butyrylcholinesterase (eqBuChE) and human butyrylcholinesterase (hBuChE) over acetylcholinesterase from electric eel (eeAChE), achieving a 21.78% inhibition at a concentration of 10 μM[1]. Additionally, at the same concentration, this compound impedes the aggregation of full-length tau protein by 44.4%[1], showcasing its potential as a multifunctional therapeutic agent for AD. |
Molecular Weight | 430.636 |
Formula | C29H38N2O |
Cas No. | 2205015-77-4 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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