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N-(m-PEG4)-N'-(DBCO-PEG4)-Cy5

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Catalog No. T18428Cas No. 2107273-76-5

N-(m-PEG4)-N'-(DBCO-PEG4)-Cy5 is a polyethylene glycol-based linker used in the synthesis of Proteolysis Targeting Chimeras (PROTACs) [1].

N-(m-PEG4)-N'-(DBCO-PEG4)-Cy5

N-(m-PEG4)-N'-(DBCO-PEG4)-Cy5

😃Good
Catalog No. T18428Cas No. 2107273-76-5
N-(m-PEG4)-N'-(DBCO-PEG4)-Cy5 is a polyethylene glycol-based linker used in the synthesis of Proteolysis Targeting Chimeras (PROTACs) [1].
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Product Introduction

Bioactivity
Description
N-(m-PEG4)-N'-(DBCO-PEG4)-Cy5 is a polyethylene glycol-based linker used in the synthesis of Proteolysis Targeting Chimeras (PROTACs) [1].
In vitro
PROTACs consist of two distinct ligands connected by a linker; one targets an E3 ubiquitin ligase, while the other targets the desired protein. They leverage the intracellular ubiquitin-proteasome system to selectively degrade target proteins [1].
Chemical Properties
Molecular Weight1087.78
FormulaC63H79ClN4O10
Cas No.2107273-76-5
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords

PEGsN(mPEG4)N'(DBCOPEG4)Cy5N-(m-PEG4)-N'-(DBCO-PEG4)-Cy5N-(m-PEG-4)-N'-(DBCO-PEG4)-Cy5N (m PEG4) N' (DBCO PEG4) Cy5
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