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Pack Size | Price | Availability | Quantity |
---|---|---|---|
2 mg | $53 | 5 days | |
5 mg | $108 | 7-10 days |
Description | N-Arachidonyl maleimide is a potent, irreversible monoacylglycerol lipase (MAGL) inhibitor with an IC 50 value of 140 nM [1]. |
In vitro | N-Arachidonyl maleimide, a presumed MAGL inhibitor, is utilized for adjusting the impact of 2-arachidonyl glycerol (2-AG). It elevates endogenous 2-AG levels in the brain and inhibits cerebellar membrane-mediated 2-AG degradation effectively at a low concentration (IC 50, 140 nM) [1]. |
In vivo | 2-AG (1, 3, and 10 mg/kg) produces significant and dose-dependent hypothermia, inhibition of locomotor activity, antinociception, and catalepsy when combined with a 1 mg/kg dose of N-Arachidonyl maleimide [1]. |
Molecular Weight | 369.54 |
Formula | C24H35NO2 |
Cas No. | 876305-42-9 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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