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N-methyl-2-HOBA (hydrochloride)

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Catalog No. T35967Cas No. 63989-87-7

N-methyl-2-HOBA is a methylated form of the isoketal scavenger 2-HOBA .1It has low reactivity with isoketals and has no effect on hypertension induced by angiotensin II . N-methyl-2-HOBA has been used as a negative control for the activity of 2-HOBA in a mouse model of hypertension.

N-methyl-2-HOBA (hydrochloride)

N-methyl-2-HOBA (hydrochloride)

😃Good
Catalog No. T35967Cas No. 63989-87-7
N-methyl-2-HOBA is a methylated form of the isoketal scavenger 2-HOBA .1It has low reactivity with isoketals and has no effect on hypertension induced by angiotensin II . N-methyl-2-HOBA has been used as a negative control for the activity of 2-HOBA in a mouse model of hypertension.
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Product Introduction

Bioactivity
Description
N-methyl-2-HOBA is a methylated form of the isoketal scavenger 2-HOBA .1It has low reactivity with isoketals and has no effect on hypertension induced by angiotensin II . N-methyl-2-HOBA has been used as a negative control for the activity of 2-HOBA in a mouse model of hypertension.
1.Kirabo, A., Fontana, V., de Faria, A.P.C., et al.DC isoketal-modified proteins activate T cells and promote hypertensionJ. Clin. Invest.124(10)4642-4656(2014)
Chemical Properties
Molecular Weight173.64
FormulaC8H12ClNO
Cas No.63989-87-7
Relative Density.1.059g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 50 mg/mL (287.95 mM), Sonication is recommended.
PBS (pH 7.2): 10 mg/mL (57.59 mM), Sonication is recommended.
DMF: 50 mg/mL (287.95 mM), Sonication is recommended.
Ethanol: 20 mg/mL (115.18 mM), Sonication is recommended.
Solution Preparation Table
PBS (pH 7.2)/Ethanol/DMSO/DMF
1mg5mg10mg50mg
1 mM5.7590 mL28.7952 mL57.5904 mL287.9521 mL
5 mM1.1518 mL5.7590 mL11.5181 mL57.5904 mL
10 mM0.5759 mL2.8795 mL5.7590 mL28.7952 mL
20 mM0.2880 mL1.4398 mL2.8795 mL14.3976 mL
50 mM0.1152 mL0.5759 mL1.1518 mL5.7590 mL
Ethanol/DMSO/DMF
1mg5mg10mg50mg
100 mM0.0576 mL0.2880 mL0.5759 mL2.8795 mL

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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Keywords

N-methyl-2-HOBANmethyl2HOBA (hydrochloride)N methyl 2 HOBA (hydrochloride)
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