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Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 μg | $413 | 35 days | |
50 μg | $783 | 35 days | |
100 μg | $1,480 | 35 days |
Description | Produced by neutrophils, macrophages, mast cells, and by transcellular metabolism in platelets, leukotriene C4 (LTC4) is the parent cysteinyl leukotriene formed by the LTC4 synthase-catalyzed conjugation of glutathione to LTA4. It is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) and exhibits potent smooth muscle contracting activity. LTC4, however, is rapidly metabolized to LTD4 and LTE4, which makes the characterization of LTC4 pharmacology difficult. N-methyl Leukotriene C4 (N-methyl LTC4) is a synthetic analog of LTC4 that is not readily metabolized to LTD4 and LTE4.It acts as a potent and selective CysLT2 receptor agonist exhibiting EC50 values of 122 and > 2,000 nM at the human CysLT2 and CysLT1 receptors, respectively. It has essentially the same potency as LTC4 at both the human and murine receptors CysLT2 receptors. N-methyl LTC4 is potent and active in vivo, causing vascular leak in mice overexpressing the human CysLT2 receptor but not in CysLT2 receptor knockout mice. |
Alias | N-methyl Leukotriene C4 |
Molecular Weight | 639.8 |
Formula | C31H49N3O9S |
Cas No. | 131391-65-6 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
Solubility Information | DMF: 50 mg/mL DMSO: 50 mg/mL PBS (pH 7.2): 100 μg/mL Ethanol:H2O (95:5): 2 mg/mL Ethanol: 1 mg/mL |
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