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N3-PEG4-C2-NH2 (PROTAC Linker 20) is a PEG-based linker compound used in the synthesis of PROTACs, enabling efficient conjugation and acting as a bridge between the target protein and the E3 ligase, thereby facilitating targeted protein degradation[1].
Description | N3-PEG4-C2-NH2 (PROTAC Linker 20) is a PEG-based linker compound used in the synthesis of PROTACs, enabling efficient conjugation and acting as a bridge between the target protein and the E3 ligase, thereby facilitating targeted protein degradation[1]. |
In vitro | PROTACs, comprising two ligands joined by a linker—one for an E3 ubiquitin ligase and the other for the target protein—utilize the intracellular ubiquitin-proteasome system to selectively degrade target proteins [1]. |
Alias | PROTAC Linker 20 |
Molecular Weight | 262.31 |
Formula | C10H22N4O4 |
Cas No. | 951671-92-4 |
Relative Density. | 1.10 g/cm3 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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