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Pack Size | Price | Availability | Quantity |
---|---|---|---|
100 mg | $29 | 7-10 days |
Description | Nα,Nα-Bis(carboxymethyl)-L-lysine is a potent competitive inhibitor of bitter taste receptor 4, with an IC50 of 59 nM, and is utilized in studies related to bitter taste receptors [1] [2] [3]. |
In vitro | Nα,Nα-Bis(carboxymethyl)-L-lysine at 59 nM reduced baseline activity by 40% in the H214A mutant of T2R4 [1]. Additionally, Nα,Nα-Bis(carboxymethyl)-L-lysine at 60 nM for 15 minutes inhibited the quinine-induced reduction of Rac1 basal activation in HEK293T cells expressing T2R4 and Ga16/44, but not in wild-type HEK293T cells [2]. |
In vivo | Nα,Nα-Bis(carboxymethyl)-L-lysine (10 μM) does not alter the licking response to bitter substances in adult C57BL6/J mice [3]. |
Molecular Weight | 262.26 |
Formula | C10H18N2O6 |
Cas No. | 113231-05-3 |
Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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