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nAChR agonist CMPI hydrochloride

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Catalog No. T39771Cas No. 2250025-94-4

CMPI hydrochloride, a potent and selective nAChR agonist, functions as a positive allosteric modulator (PAM) specifically targeting the α4:α4 subunit interface of the nAChR. It enhances the response of the (α4)3(β2)2 nAChR to acetylcholine (ACh) (10 μM) with an EC 50 of 0.26 μM. With its potential for researching nicotine dependence and various neuropsychiatric conditions linked to reduced brain cholinergic activity, CMPI hydrochloride stands as a significant compound in neurological research.

nAChR agonist CMPI hydrochloride

nAChR agonist CMPI hydrochloride

😃Good
Catalog No. T39771Cas No. 2250025-94-4
CMPI hydrochloride, a potent and selective nAChR agonist, functions as a positive allosteric modulator (PAM) specifically targeting the α4:α4 subunit interface of the nAChR. It enhances the response of the (α4)3(β2)2 nAChR to acetylcholine (ACh) (10 μM) with an EC 50 of 0.26 μM. With its potential for researching nicotine dependence and various neuropsychiatric conditions linked to reduced brain cholinergic activity, CMPI hydrochloride stands as a significant compound in neurological research.
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Product Introduction

Bioactivity
Description
CMPI hydrochloride, a potent and selective nAChR agonist, functions as a positive allosteric modulator (PAM) specifically targeting the α4:α4 subunit interface of the nAChR. It enhances the response of the (α4)3(β2)2 nAChR to acetylcholine (ACh) (10 μM) with an EC 50 of 0.26 μM. With its potential for researching nicotine dependence and various neuropsychiatric conditions linked to reduced brain cholinergic activity, CMPI hydrochloride stands as a significant compound in neurological research.
In vitro
CMPI (0.01-10 μM) enhances the activity of (α4)3(β2)2 nAChRs, characterized by low acetylcholine sensitivity, without affecting (α4)2(β2)3 nAChRs, which exhibit high acetylcholine sensitivity, in Xenopus laevis oocytes[1]. Furthermore, CMPI (0.01-10 μM) demonstrates inhibition of (α4)2(β2)3, human muscle, and Torpedo nAChRs in Xenopus oocytes, with respective IC50 values of 0.6, 0.7, and 0.2 μM[1].
Chemical Properties
Molecular Weight379.29
FormulaC18H20Cl2N4O
Cas No.2250025-94-4
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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Keywords

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