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Naldemedine tosylate

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Catalog No. T70929Cas No. 1345728-04-2
Alias S-297995 tosylate

Naldemedine tosylate (S-297995) is an orally active μ-opioid receptor antagonist (PAMORA) with high binding affinities (K_i = 0.34, 0.43, 0.94 nM) and potent antagonist activities (IC_50 = 25.57, 7.09, 16.1 nM) towards human recombinant μ-, δ-, and κ-opioid receptors, respectively. It is utilized in research on opioid-induced constipation (OIC) and is anticipated to interact with the 3CL proenzyme encoded by the SARS-CoV-2 genome.

Naldemedine tosylate
Other Forms of Naldemedine tosylate:
NaldemedineT33583916072-89-4
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Naldemedine tosylate

😃Good
Catalog No. T70929Alias S-297995 tosylateCas No. 1345728-04-2
Naldemedine tosylate (S-297995) is an orally active μ-opioid receptor antagonist (PAMORA) with high binding affinities (K_i = 0.34, 0.43, 0.94 nM) and potent antagonist activities (IC_50 = 25.57, 7.09, 16.1 nM) towards human recombinant μ-, δ-, and κ-opioid receptors, respectively. It is utilized in research on opioid-induced constipation (OIC) and is anticipated to interact with the 3CL proenzyme encoded by the SARS-CoV-2 genome.
Pack SizePriceAvailabilityQuantity
25 mg$1,50010-14 weeks
50 mg$1,96010-14 weeks
100 mg$2,97010-14 weeks
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Product Introduction

Bioactivity
Description
Naldemedine tosylate (S-297995) is an orally active μ-opioid receptor antagonist (PAMORA) with high binding affinities (K_i = 0.34, 0.43, 0.94 nM) and potent antagonist activities (IC_50 = 25.57, 7.09, 16.1 nM) towards human recombinant μ-, δ-, and κ-opioid receptors, respectively. It is utilized in research on opioid-induced constipation (OIC) and is anticipated to interact with the 3CL proenzyme encoded by the SARS-CoV-2 genome.
AliasS-297995 tosylate
Chemical Properties
Molecular Weight742.84
FormulaC39H42N4O9S
Cas No.1345728-04-2
Storage & Solubility Information
StorageShipping with blue ice.

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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Keywords

Naldemedine TosylateS 297995 TosylateS297995 TosylateSYK-IN-IISYK-INIIS-297995 TosylateSYKIN-II
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