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Namitecan
😃Good
Catalog No. T16268Cas No. 372105-27-6
Alias ST-1968
Namitecan is an effective inhibitor of topoisomerase I. It has antitumor property.
Namitecan
😃Good
Catalog No. T16268Alias ST-1968Cas No. 372105-27-6
Namitecan is an effective inhibitor of topoisomerase I. It has antitumor property.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,620 | 10-14 weeks | |
| 50 mg | $2,110 | 10-14 weeks | |
| 100 mg | $3,380 | 10-14 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Namitecan is an effective inhibitor of topoisomerase I. It has antitumor property. |
| In vitro | Namitecan decreases a dose-dependent decrease in EGFR expression in the different cell lines[1]. Namitecan and cetuximab cooperate in inhibiting EGFR expression. ST1968 causes a comparable level of apoptosis in A431 and A431/TPT cells (IC50: 0.21 and 0.29 μM)[2]. |
| In vivo | Namitecan (10 mg/kg) combined with cetuximab (1 mg/mouse) demonstrates synergistic antitumor effects in SCC models, dependent on the EGFR gene copy number[1]. ST1968 (25 mg/kg) is associated with tolerable body weight loss and no fatal toxicity, achieving a 100% complete response rate in mice with the A431 tumor, and maintaining significant efficacy in topotecan-resistant tumors[2]. |
| Alias | ST-1968 |
| Molecular Weight | 434.44 |
| Formula | C23H22N4O5 |
| Cas No. | 372105-27-6 |
| Relative Density. | 1.51 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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