Powder: -20°C for 3 years | In solvent: -80°C for 1 year
NLRP3-IN-NBC6 is a potent, selective NLRP3 inflammasome inhibitor with IC50 of 574 nM. NLRP3-IN-NBC6 acts independently of Ca 2+. NLRP3-IN-NBC6 inhibits Nigericin -induced inflammasome activation in THP-1 cells and Imiquimod -induced IL-1β release from LPS-primed bone marrow-derived macrophages (BMDMs) [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
10 mg | 4-5 weeks | $ 553.00 | |
50 mg | 4-5 weeks | $ 2,290.00 |
Description | NLRP3-IN-NBC6 is a potent, selective NLRP3 inflammasome inhibitor with IC50 of 574 nM. NLRP3-IN-NBC6 acts independently of Ca 2+. NLRP3-IN-NBC6 inhibits Nigericin -induced inflammasome activation in THP-1 cells and Imiquimod -induced IL-1β release from LPS-primed bone marrow-derived macrophages (BMDMs) [1]. |
In vitro | In LPS-primed primary bone marrow-derived macrophages (BMDMs), the chemical NLRP3 inhibitor NLRP3-IN-NBC6 at a concentration of 10 μM and applied for 15 minutes, effectively suppresses the release of IL-1β triggered by Imiquimod. Additionally, NLRP3-IN-NBC6 fully blocks the secretion of NLRP3-dependent IL-1β in neutrophils. These neutrophils, sourced from both wild-type and NLRP3 knockout (KO) mouse bone marrow, were primed with LPS and subsequently treated with Nigericin in the presence of 10 μM NLRP3-IN-NBC6 [1]. |
Molecular Weight | 409.5 |
Formula | C18H16BCl3N2O2 |
CAS No. | 2068818-02-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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