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NBD-125
Catalog No. T60928Cas No. 2367641-24-3
NBD-125 (B-12) is a berberine analogue. NBD-125 is an RXRα activator. The IC50 value of NBD-125 in KM12C cell is 31.10 μM [1].
NBD-125
Catalog No. T60928Cas No. 2367641-24-3
NBD-125 (B-12) is a berberine analogue. NBD-125 is an RXRα activator. The IC50 value of NBD-125 in KM12C cell is 31.10 μM [1].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,520 | 6-8 weeks | |
| 50 mg | $1,980 | 6-8 weeks | |
| 100 mg | $2,500 | 6-8 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | NBD-125 (B-12) is a berberine analogue. NBD-125 is an RXRα activator. The IC50 value of NBD-125 in KM12C cell is 31.10 μM [1]. |
| In vitro | NBD-125 (B-12) demonstrates a potent ability to activate RXRα transcription and significantly suppresses colon cancer cell proliferation, making it an effective inhibitor of β-catenin signaling. Its anti-proliferative effects are observed across a range of concentrations (0-80 μM) in several colon cancer cell lines, including Km12c, HCT116, and SW620. Detailed Western Blot Analysis reveals that, after a 15-hour incubation period across varying concentrations (0-50 μM, 0-60 μM, 0-80 μM), there is a notable decrease in c-Myc and Cdc42 protein levels, indicating a disruption in cellular signaling pathways critical for cancer cell growth. |
| Molecular Weight | 327.81 |
| Formula | C19H18ClNO2 |
| Cas No. | 2367641-24-3 |
Storage & Solubility Information
| Storage | Shipping with blue ice. |
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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