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Neoseptin 3

Name: Neoseptin 3
Brand: TargetMol
SKU: T16284
Price: 101 USD
Availability: InStock
Rating: 4.5 (1 reviews)

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Catalog No. T16284Cas No. 1622863-21-1

Neoseptin 3 is an agonist of Toll-like receptor 4/myeloid differentiation factor 2 (EC50: 18.5 μM).

Neoseptin 3

🥰Excellent

Catalog No. T16284Cas No. 1622863-21-1

Neoseptin 3 is an agonist of Toll-like receptor 4/myeloid differentiation factor 2 (EC50: 18.5 μM).

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Product Introduction

Bioactivity

Description	Neoseptin 3 is an agonist of Toll-like receptor 4/myeloid differentiation factor 2 (EC50: 18.5 μM).
Targets&IC50	mTLR4/MD-2:(EC50)18.5 μM
In vitro	Neoseptin-3 causes TNFα production by macrophages in a concentration-dependent manner. TANK-binding kinase 1 (TBK1) and IRF3 phosphorylation also enhance in response to Neoseptin-3. Neoseptin-3 leads to phosphorylation of IκB kinases α (IKKα), IKKβ, p38, c-Jun N-terminal kinase (JNK), and ERK, and degradation of IκBα, consistent with activation of MAPK and canonical NF-κB signaling. .

Chemical Properties

Molecular Weight	474.59
Formula	C₂₉H₃₄N₂O₄
Cas No.	1622863-21-1
Relative Density.	1.174 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 100 mg/mL (210.71 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1071 mL	10.5354 mL	21.0708 mL	105.3541 mL
5 mM	0.4214 mL	2.1071 mL	4.2142 mL	21.0708 mL
10 mM	0.2107 mL	1.0535 mL	2.1071 mL	10.5354 mL
20 mM	0.1054 mL	0.5268 mL	1.0535 mL	5.2677 mL
50 mM	0.0421 mL	0.2107 mL	0.4214 mL	2.1071 mL
100 mM	0.0211 mL	0.1054 mL	0.2107 mL	1.0535 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Neoseptin 3