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Nesosteine Lithium
Catalog No. T33647L
Alias Nesosteine Lithium(84233-61-4 Free baes)
Nesosteine Lithium is a novel mucoregulatory that inhibits Herxheimer microconvulsions in guinea pigs and inhibits ovalbumin-induced histamine release from sensitized trachea.Nesosteine Lithium protects against ovalbumin-induced bronchospasm but is ineffective against histamine- and acetylcholine-induced bronchospasm. Nesosteine Lithium protected against ovalbumin-induced bronchospasm but not histamine- and acetylcholine-induced bronchospasm.
Nesosteine Lithium
Catalog No. T33647LAlias Nesosteine Lithium(84233-61-4 Free baes)
Nesosteine Lithium is a novel mucoregulatory that inhibits Herxheimer microconvulsions in guinea pigs and inhibits ovalbumin-induced histamine release from sensitized trachea.Nesosteine Lithium protects against ovalbumin-induced bronchospasm but is ineffective against histamine- and acetylcholine-induced bronchospasm. Nesosteine Lithium protected against ovalbumin-induced bronchospasm but not histamine- and acetylcholine-induced bronchospasm.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $350 | In Stock | |
| 5 mg | $828 | In Stock | |
| 10 mg | $1,130 | In Stock | |
| 25 mg | $1,590 | In Stock | |
| 50 mg | $1,980 | In Stock | |
| 100 mg | $2,500 | In Stock | |
| 500 mg | $4,900 | In Stock |
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Purity:98.57%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Nesosteine Lithium is a novel mucoregulatory that inhibits Herxheimer microconvulsions in guinea pigs and inhibits ovalbumin-induced histamine release from sensitized trachea.Nesosteine Lithium protects against ovalbumin-induced bronchospasm but is ineffective against histamine- and acetylcholine-induced bronchospasm. Nesosteine Lithium protected against ovalbumin-induced bronchospasm but not histamine- and acetylcholine-induced bronchospasm. |
| In vitro | Nesosteine (10(-5) M) inhibits ovalbumin-induced histamine release in the trachea of sensitized animals. In the same preparation, the drug is ineffective against the contractions induced by histamine or acetylcholine.[2] |
| In vivo | Nesosteine (5-50 mg/kg; guinea-pigs) is able to protect sensitized animals from ovalbumin-induced bronchospasm. On the other hand, the drug is ineffective against the bronchospasm induced by histamine and acetylcholine.[2] |
| Alias | Nesosteine Lithium(84233-61-4 Free baes) |
| Molecular Weight | 243.22 |
| Formula | C11H10LiNO3S |
Storage & Solubility Information
| Storage | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 7.5 mg/mL (30.84 mM)  | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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