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NH-bis(PEG2-C2-acid) is a PEG-based linker essential for PROTACs, facilitating the conjugation of two critical ligands and enabling selective protein degradation through the ubiquitin-proteasome system within cells.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
100 mg | Inquiry | Backorder | |
500 mg | Inquiry | Backorder |
Description | NH-bis(PEG2-C2-acid) is a PEG-based linker essential for PROTACs, facilitating the conjugation of two critical ligands and enabling selective protein degradation through the ubiquitin-proteasome system within cells. |
In vitro | PROTACs consist of two ligands linked by a connector: one binds to an E3 ubiquitin ligase, and the other to the target protein. They leverage the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
Molecular Weight | 337.37 |
Formula | C14H27NO8 |
Cas No. | 1919044-99-7 |
Relative Density. | 1.191 g/cm3 (Predicted) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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