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NH2-PEG4-Glu(OH)-NH-m-PEG24

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Catalog No. T18490

NH2-PEG4-Glu(OH)-NH-m-PEG24 is a PEG-based PROTAC linker suitable for PROTAC synthesis [1].

NH2-PEG4-Glu(OH)-NH-m-PEG24

NH2-PEG4-Glu(OH)-NH-m-PEG24

😃Good
Catalog No. T18490
NH2-PEG4-Glu(OH)-NH-m-PEG24 is a PEG-based PROTAC linker suitable for PROTAC synthesis [1].
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Product Introduction

Bioactivity
Description
NH2-PEG4-Glu(OH)-NH-m-PEG24 is a PEG-based PROTAC linker suitable for PROTAC synthesis [1].
In vitro
PROTACs consist of two ligands connected by a linker: one targets an E3 ubiquitin ligase, and the other targets the desired protein. By leveraging the intracellular ubiquitin-proteasome system, PROTACs achieve selective degradation of the target proteins [1].
Chemical Properties
Molecular Weight1464.72
FormulaC65H129N3O32
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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2 Enter the in vivo formulation:
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Keywords

NH2 PEG4 Glu(OH) NH m PEG24NH2PEG4Glu(OH)NHmPEG24NH-2-PEG4-Glu(OH)-NH-m-PEG24NH2-PEG4-Glu(OH)-NH-m-PEG24
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