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NLA 1

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Catalog No. T33698Cas No. 140448-36-8
Alias NLA-1, NLA1

NLA 1 is a bioreductive compound, a 2-nitroimidazole radiosensitizer embedded in targeted DNA.NLA-1 reversibly binds DNA with an affinity similar to that of 9-aminoacridine and is approximately 1,000 times more potent as a cytotoxin than MISO.

NLA 1

NLA 1

😃Good
Catalog No. T33698Alias NLA-1, NLA1Cas No. 140448-36-8
NLA 1 is a bioreductive compound, a 2-nitroimidazole radiosensitizer embedded in targeted DNA.NLA-1 reversibly binds DNA with an affinity similar to that of 9-aminoacridine and is approximately 1,000 times more potent as a cytotoxin than MISO.
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Product Introduction

Bioactivity
Description
NLA 1 is a bioreductive compound, a 2-nitroimidazole radiosensitizer embedded in targeted DNA.NLA-1 reversibly binds DNA with an affinity similar to that of 9-aminoacridine and is approximately 1,000 times more potent as a cytotoxin than MISO.
AliasNLA-1, NLA1
Chemical Properties
Molecular Weight383.84
FormulaC19H18ClN5O2
Cas No.140448-36-8
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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NLA 1
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