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NSC15520

Name: NSC15520
Brand: TargetMol
SKU: T81640
Price: 47 EUR
Availability: InStock
Rating: 4.5 (1 reviews)

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Catalog No. T81640Cas No. 730960-98-2

Alias NSC 15520

NSC15520 is a replication protein A (RPA) inhibitor that inhibits the binding of Rad9-GST and p53-GST fusion proteins to the N-terminal DNA-binding domain (DBD) of RPA, inhibits helical destabilization of double-stranded DNA (dsDNA) oligonucleotides, and can be used to study DNA damage repair.

NSC15520

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Catalog No. T81640Alias NSC 15520Cas No. 730960-98-2

Pack Size	Price	Availability
1 mg	$78	35 days
5 mg	$233	35 days
10 mg	$273	35 days
25 mg	$575	35 days

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COA

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity

Description	NSC15520 is a replication protein A (RPA) inhibitor that inhibits the binding of Rad9-GST and p53-GST fusion proteins to the N-terminal DNA-binding domain (DBD) of RPA, inhibits helical destabilization of double-stranded DNA (dsDNA) oligonucleotides, and can be used to study DNA damage repair.
Targets&IC50	RPA with the GST-p53 peptide:10 μM
In vitro	NSC15520 blocks the interaction of RPA with the GST-p53 peptide with an IC50 of 10 μM. NSC15520 (0-400 μM, treatment for 5 min) inhibits helix destabilizing activity and also inhibits RPA binding to dsDNA 30-mer.[1]
Alias	NSC 15520

Chemical Properties

Molecular Weight	418.52
Formula	C₂₄H₃₄O₆
Cas No.	730960-98-2
Smiles	O=C(O)C1C2C(=CC3(CCC4C(C(=O)O)(C)CCCC4(C)C3C2)C1C(=O)O)C(C)C

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 20.00 mg/mL (47.79 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3894 mL	11.9469 mL	23.8937 mL	119.4686 mL
5 mM	0.4779 mL	2.3894 mL	4.7787 mL	23.8937 mL
10 mM	0.2389 mL	1.1947 mL	2.3894 mL	11.9469 mL
20 mM	0.1195 mL	0.5973 mL	1.1947 mL	5.9734 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc