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NSC15520
Catalog No. T81640Cas No. 730960-98-2
NSC15520, a small-molecule inhibitor of Replication Protein A (RPA), selectively targets the N-terminal DNA binding domain (DBD) of RPA, preventing its interaction with p53 and RAD9. Additionally, NSC15520 impedes the helix destabilization of duplex DNA (dsDNA) oligonucleotides, playing a role in processes such as DNA replication, repair, recombination, and the DNA damage response signaling pathway [1].
NSC15520
Catalog No. T81640Cas No. 730960-98-2
NSC15520, a small-molecule inhibitor of Replication Protein A (RPA), selectively targets the N-terminal DNA binding domain (DBD) of RPA, preventing its interaction with p53 and RAD9. Additionally, NSC15520 impedes the helix destabilization of duplex DNA (dsDNA) oligonucleotides, playing a role in processes such as DNA replication, repair, recombination, and the DNA damage response signaling pathway [1].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $78 | 35 days | |
| 5 mg | $233 | 35 days | |
| 10 mg | $273 | 35 days | |
| 25 mg | $575 | 35 days |
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Product Introduction
Bioactivity
Chemical Properties
| Description | NSC15520, a small-molecule inhibitor of Replication Protein A (RPA), selectively targets the N-terminal DNA binding domain (DBD) of RPA, preventing its interaction with p53 and RAD9. Additionally, NSC15520 impedes the helix destabilization of duplex DNA (dsDNA) oligonucleotides, playing a role in processes such as DNA replication, repair, recombination, and the DNA damage response signaling pathway [1]. |
| In vitro | NSC15520, at concentrations ranging from 10 to 0.5 x 10^-3.5 M, inhibits the interaction between RPA and the GST-p53 peptide with an IC50 of 10 μM [1]. |
| Molecular Weight | 418.52 |
| Formula | C24H34O6 |
| Cas No. | 730960-98-2 |
Storage & Solubility Information
| Storage | store at low temperature | Shipping with blue ice. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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