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Nusinersen

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Catalog No. T38656Cas No. 1258984-36-9

Nusinersen, an antisense oligonucleotide drug, modifies the pre-messenger RNA (pre-mRNA) splicing of the SMN2 gene, thereby enhancing the production of the full-length Survival Motor Neuron (SMN) protein.

Nusinersen

Nusinersen

😃Good
Catalog No. T38656Cas No. 1258984-36-9
Nusinersen, an antisense oligonucleotide drug, modifies the pre-messenger RNA (pre-mRNA) splicing of the SMN2 gene, thereby enhancing the production of the full-length Survival Motor Neuron (SMN) protein.
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Product Introduction

Bioactivity
Description
Nusinersen, an antisense oligonucleotide drug, modifies the pre-messenger RNA (pre-mRNA) splicing of the SMN2 gene, thereby enhancing the production of the full-length Survival Motor Neuron (SMN) protein.
In vitro
Nusinersen, an SMN-ASO, enhances SMN levels by inhibiting an intronic splice silencer within SMN2. This action promotes the inclusion of exon 7, leading to the production of full-length SMN2 transcripts[2].
Chemical Properties
Cas No.1258984-36-9
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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