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NVP-CLR457

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Catalog No. T62816Cas No. 1453082-52-4

NVP-CLR457 (compound 40) is an orally active, balanced pan-class I PI3K inhibitor with antitumor effects, demonstrating a significant dose-dependent PK/PD/efficacy relationship.

NVP-CLR457

NVP-CLR457

😃Good
Catalog No. T62816Cas No. 1453082-52-4
NVP-CLR457 (compound 40) is an orally active, balanced pan-class I PI3K inhibitor with antitumor effects, demonstrating a significant dose-dependent PK/PD/efficacy relationship.
Pack SizePriceAvailabilityQuantity
25 mg$2,1406-8 weeks
50 mg$2,7856-8 weeks
100 mg$3,5206-8 weeks
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Product Introduction

Bioactivity
Description
NVP-CLR457 (compound 40) is an orally active, balanced pan-class I PI3K inhibitor with antitumor effects, demonstrating a significant dose-dependent PK/PD/efficacy relationship.
Chemical Properties
Molecular Weight455.39
FormulaC18H20F3N7O4
Cas No.1453082-52-4
Storage & Solubility Information
StorageShipping with blue ice.

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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