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NVP-DPP728 dihydrochloride

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Catalog No. T39481Cas No. 207556-62-5
Alias NVP-DPP728 dihydrochloride

NVP-DPP728 dihydrochloride is a highly potent, selective, and orally active inhibitor of dipeptidyl peptidase IV (DPP-IV), with a binding affinity (K i ) of 11 nM. This compound proves useful for investigating diabetes mellitus in research studies.

NVP-DPP728 dihydrochloride

NVP-DPP728 dihydrochloride

😃Good
Catalog No. T39481Alias NVP-DPP728 dihydrochlorideCas No. 207556-62-5
NVP-DPP728 dihydrochloride is a highly potent, selective, and orally active inhibitor of dipeptidyl peptidase IV (DPP-IV), with a binding affinity (K i ) of 11 nM. This compound proves useful for investigating diabetes mellitus in research studies.
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Product Introduction

Bioactivity
Description
NVP-DPP728 dihydrochloride is a highly potent, selective, and orally active inhibitor of dipeptidyl peptidase IV (DPP-IV), with a binding affinity (K i ) of 11 nM. This compound proves useful for investigating diabetes mellitus in research studies.
Targets&IC50
DPP4:11 nM (Ki)
In vitro
NVPDPP728 selectively inhibits DPP-IV in both human and rat plasma, exhibiting high potency with IC50 values between 5-10 nM. Its selectivity exceeds 15,000-fold compared to DPP-II and various proline-cleaving proteases[1].
In vivo
NVP-DPP728 (3.72 mg/kg; p.o.) suppresses DPP-IV, likely amplify ng endogenous GLP-1 effects to enhance insulin secretion and glucose tolerance in obese (fa/fa) and lean (FA/?) Zucker rats, as evidenced by inhibited plasma DPP-IV activity.
AliasNVP-DPP728 dihydrochloride
Chemical Properties
Molecular Weight371.27
FormulaC15H20Cl2N6O
Cas No.207556-62-5
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
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2 Enter the in vivo formulation:
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

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