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NW16
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Catalog No. T203161
NW16 is an orally active STAT3 inhibitor with a Kd of 11.0 μM. It causes cell cycle arrest at the S phase, induces apoptosis in HCT116 cells, and inhibits the proliferation of cancer cells HCT116, A549, and B16, with IC50 values of 0.28 μM, 1.22 μM, and 9.86 μM, respectively. NW16 promotes the production of ROS and inhibits the PI3K/AKT signaling pathway, demonstrating antitumor activity in mouse models.
NW16
NW16
😃Good
Catalog No. T203161
NW16 is an orally active STAT3 inhibitor with a Kd of 11.0 μM. It causes cell cycle arrest at the S phase, induces apoptosis in HCT116 cells, and inhibits the proliferation of cancer cells HCT116, A549, and B16, with IC50 values of 0.28 μM, 1.22 μM, and 9.86 μM, respectively. NW16 promotes the production of ROS and inhibits the PI3K/AKT signaling pathway, demonstrating antitumor activity in mouse models.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 mg | Inquiry | Backorder | |
| 50 mg | Inquiry | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
| Description | NW16 is an orally active STAT3 inhibitor with a Kd of 11.0 μM. It causes cell cycle arrest at the S phase, induces apoptosis in HCT116 cells, and inhibits the proliferation of cancer cells HCT116, A549, and B16, with IC50 values of 0.28 μM, 1.22 μM, and 9.86 μM, respectively. NW16 promotes the production of ROS and inhibits the PI3K/AKT signaling pathway, demonstrating antitumor activity in mouse models. |
| Targets&IC50 | STAT3:11 μM (Kd) |
| Molecular Weight | 336.3 |
| Formula | C18H12N2O5 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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