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Ociperlimab

Catalog No. T78324Cas No. 2342597-93-5

Ociperlimab, a humanized IgG1 anti-TIGIT antibody, exhibits high affinity for the extracellular domain of human TIGIT, with a dissociation constant (K_D) of 0.135 nM. It effectively inhibits the interaction between TIGIT and its ligands PVR or PVR-L2, and is utilized in cancer research [1] [2].

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Product Introduction

Bioactivity

Description	Ociperlimab, a humanized IgG1 anti-TIGIT antibody, exhibits high affinity for the extracellular domain of human TIGIT, with a dissociation constant (K_D) of 0.135 nM. It effectively inhibits the interaction between TIGIT and its ligands PVR or PVR-L2, and is utilized in cancer research [1] [2].
In vitro	Ociperlimab (BGB-A1217; 0-10 μg/mL) enhances the secretion of IFN-γ by cytomegalovirus-specific T cells [1]. At concentrations of 1-1000 ng/mL, ociperlimab activates natural killer cells and monocytes in an Fc-dependent manner [1]. Additionally, ociperlimab removes TIGIT from the surface of T cells through Fc-dependent endocytosis in vitro [1].
In vivo	Ociperlimab (BGB-A1217; doses of 3 and 10 mg/kg; administered intraperitoneally) elicits antitumor efficacy through an Fc-dependent mechanism in CT26 WT and MC38 tumor-bearing humanized TIGIT-knockin mice [1].
Alias	BGB-A1217

Chemical Properties

Cas No.

2342597-93-5

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

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Keywords

OciperlimabBGB-A-1217BGB-A 1217