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ODN 1982
Catalog No. T84771Cas No. 207623-15-2
ODN 1982, an unmethylated oligodeoxyribonucleotide (ODN) lacking a CpG motif, serves as a key component in the preparation of DNA vaccines. This compound effectively inhibits R-848 signaling. Its sequence is denoted as 5'-tccaggacttctctcaggtt-3' [1] [2].
ODN 1982
ODN 1982
Catalog No. T84771Cas No. 207623-15-2
ODN 1982, an unmethylated oligodeoxyribonucleotide (ODN) lacking a CpG motif, serves as a key component in the preparation of DNA vaccines. This compound effectively inhibits R-848 signaling. Its sequence is denoted as 5'-tccaggacttctctcaggtt-3' [1] [2].
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Bioactivity
Chemical Properties
| Description | ODN 1982, an unmethylated oligodeoxyribonucleotide (ODN) lacking a CpG motif, serves as a key component in the preparation of DNA vaccines. This compound effectively inhibits R-848 signaling. Its sequence is denoted as 5'-tccaggacttctctcaggtt-3' [1] [2]. |
| In vitro | ODN 1982 at concentrations ranging from 0.1 to 5 μM does not affect NF-κB activation in HEK293 cells expressing human TLR7 [2]. Additionally, when administered in combination with Loxoribine at concentrations of 0.1-10 μM for 24 hours, ODN 1982 fails to elevate IL-12p40 levels beyond medium background levels and results in a scant increase in TNF-positive monocytes [2]. |
| Molecular Weight | 6364.1 |
| Cas No. | 207623-15-2 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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