ODN 1982, an unmethylated oligodeoxyribonucleotide (ODN) lacking a CpG motif, serves as a key component in the preparation of DNA vaccines. This compound effectively inhibits R-848 signaling. Its sequence is denoted as 5'-tccaggacttctctcaggtt-3' [1] [2].

ODN 1982 at concentrations ranging from 0.1 to 5 μM does not affect NF-κB activation in HEK293 cells expressing human TLR7 [2]. Additionally, when administered in combination with Loxoribine at concentrations of 0.1-10 μM for 24 hours, ODN 1982 fails to elevate IL-12p40 levels beyond medium background levels and results in a scant increase in TNF-positive monocytes [2].