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Orexin receptor antagonist 3

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Catalog No. T62453Cas No. 1293282-55-9

Orexin receptor antagonist 3 (example 216) functions as an orexin receptor antagonist.

Orexin receptor antagonist 3

Orexin receptor antagonist 3

😃Good
Catalog No. T62453Cas No. 1293282-55-9
Orexin receptor antagonist 3 (example 216) functions as an orexin receptor antagonist.
Pack SizePriceAvailabilityQuantity
25 mg$1,620 6-8 weeks
50 mg$2,110 6-8 weeks
100 mg$2,988 6-8 weeks
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Questions
QWhy can't I see anything in the vial when I receive small-sized products?
ADue to the small pack, the powder may be highly dispersed during shipping due to static electricity and may adhere to the vial. Please centrifuge and add an appropriate solvent to fully dissolve the product and prepare the stock solution.
QAnimals cannot tolerate DMSO well. How should the dosage of DMSO be controlled during administration?
AFor normal mice, the concentration of DMSO should be kept below 10%. For nude mice, transgenic mice, or mice with weak tolerance, the concentration of DMSO should be kept below 2%. For inhibitors being used for the first time, it is recommended to perform a solvent-negative control experiment to confirm that the solvent has no nonspecific effects on the animals.
QCan high-temperature sterilization be used for inhibitors?
AMost products are synthesized by chemical methods
Qwhat frequency should sonication be used?
AIt is recommended to use the conventional ultrasound cleaning frequency
QCan PEG400 be used instead of PEG300?
APEG300 has moderate viscosity, which facilitates the dissolution and administration of drugs, while also providing good tolerability without adverse effects on animals. PEG400 can replace PEG300. PEG600 is not very recommended because its melting point is close to room temperature.
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Product Introduction

Bioactivity
Description
Orexin receptor antagonist 3 (example 216) functions as an orexin receptor antagonist.
Chemical Properties
Molecular Weight434.45
FormulaC21H22N8O3
Cas No.1293282-55-9
Storage & Solubility Information
StorageShipping with blue ice.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
%Tween 80
%ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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