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Osteostatin

Name: Osteostatin
Brand: TargetMol
SKU: T81592
Price: 53 USD
Availability: InStock
Rating: 4.5 (1 reviews)

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Catalog No. T81592Cas No. 138949-73-2

Alias PTHrP (107–111)

Osteostatin, derived from parathyroid hormone-related protein (PTHrP) 107-111, has demonstrated properties conducive to bone repair in animal models presenting with bone defects and exhibits efficacy in mitigating bone erosion associated with inflammatory arthritis. Additionally, it possesses the capacity to inhibit both collagen-induced arthritis and direct osteoclastic bone resorption, marking its potential utility in inflammation and immunology research [1] [2] [3] [4].

Osteostatin

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Catalog No. T81592Alias PTHrP (107–111)Cas No. 138949-73-2

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Product Introduction

Bioactivity

Description	Osteostatin, derived from parathyroid hormone-related protein (PTHrP) 107-111, has demonstrated properties conducive to bone repair in animal models presenting with bone defects and exhibits efficacy in mitigating bone erosion associated with inflammatory arthritis. Additionally, it possesses the capacity to inhibit both collagen-induced arthritis and direct osteoclastic bone resorption, marking its potential utility in inflammation and immunology research [1] [2] [3] [4].
In vitro	Osteostatin (100, 250, 500 nM, 7-9 days) reduces osteoclast differentiation in a concentration-dependent manner [2].
In vivo	Osteostatin (80 or 120 μg/kg; subcutaneously injected daily post-onset of the disease for 13 days) reduced the severity of arthritis and cartilage and bone degradation[4].
Alias	PTHrP (107–111)

Chemical Properties

Molecular Weight	619.67
Formula	C₂₇H₄₁N₉O₈
Cas No.	138949-73-2

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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