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Oxyfedrine

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Catalog No. T60795Cas No. 15687-41-9

Oxyfedrine is an orally active β-adrenoreceptor agonist. Oxyfedrine is a vasodilator that reduces coronary vessels tonicity that can be used in cardiovascular disease research[1] [2].

Oxyfedrine

Oxyfedrine

😃Good
Catalog No. T60795Cas No. 15687-41-9
Oxyfedrine is an orally active β-adrenoreceptor agonist. Oxyfedrine is a vasodilator that reduces coronary vessels tonicity that can be used in cardiovascular disease research[1] [2].
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25 mg3.199 €6-8 weeks
50 mg3.781 €6-8 weeks
100 mg5.225 €6-8 weeks
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Product Introduction

Bioactivity
Description
Oxyfedrine is an orally active β-adrenoreceptor agonist. Oxyfedrine is a vasodilator that reduces coronary vessels tonicity that can be used in cardiovascular disease research[1] [2].
In vitro
Oxyfedrine, at a concentration of 50 μM for 48 hours, reduces aldehyde dehydrogenase (ALDH) activity in HCT116 and HSC-4 cells, and functions as a sensitizer to GSH-depleting agents, consequently enhancing cell death in these cell lines when used in combination with such drugs [1]. Additionally, oxyfedrine, within a dosage range of 0-1 μg/mL, hampers spontaneous myogenic activity in the rat isolated portal vein [4].
In vivo
Oxyfedrine, administered at various dosages and by different routes across multiple studies, exhibits diverse pharmacological actions. At a dosage of 14 mg/kg through oral administration (p.o.) for 3-4 weeks in cats, oxyfedrine demonstrates anti-anginal properties [2]. In a model utilizing HCT116 cell xenograft mice, oxyfedrine (10 mg/kg, intraperitoneally i.p.) combined with sulfasalazine (SSZ, 350 mg/kg, i.p.) effectively suppresses tumor growth [1]. Furthermore, at a lower dosage of 1 mg/kg administered intravenously (i.v.), oxyfedrine reduces both arterial and venous blood viscosity under conditions of ice water-induced stress in rats [3]. Detailed results from the cat model indicate oxyfedrine decreases systolic and diastolic blood pressures, while increasing heart rate and cardiac output [2].
Chemical Properties
Molecular Weight313.39
FormulaC19H23NO3
Cas No.15687-41-9
Storage & Solubility Information
StorageShipping with blue ice.

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