Oxyntomodulin (bovine, porcine) TFA is a 37-amino acid peptide hormone that functions as a glucagon-like peptide 1 (GLP-1) receptor agonist [1].

Oxyntomodulin (bovine, porcine), a gut-derived postprandial peptide hormone, simultaneously targets and activates the glucagon-like peptide-1 receptor (GLP1R) and the glucagon receptor (GCGR). This dual activation leads to more pronounced body weight reduction than that observed with selective GLP1R agonists alone. Produced primarily in the L-cells of the gut, oxyntomodulin is generated through the enzymatic processing of the preproglucagon precursor by prohormone convertase 1/3. As a full agonist on human GLP1R and GCGR in overexpressing cell lines, oxyntomodulin facilitates cAMP accumulation, albeit with lower affinity compared to GLP-1 and glucagon [1].