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Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | Inquiry | Backorder | |
50 mg | Inquiry | Backorder |
Description | P-gp Inhibitor 13, a P-glycoprotein antagonist, can counteract paclitaxel resistance in A2780/T cells, proving valuable for advanced acute myeloid leukemia research [1]. |
In vitro | P-gp inhibitor 13 (Compound 27f) significantly chemosensitized A2780/T cells with an IC50 of 0.010 μM [1], increased paclitaxel and rhodamine 123 accumulation by inhibiting P-gp to reverse multidrug resistance (MDR) [1], exhibited minimal cardiotoxicity [1], and showed concentration-dependent MDR reversal at 2.5, 5, 10, and 20 μM in A2780/T cells [1]. |
Molecular Weight | 546.61 |
Formula | C32H34O8 |
Cas No. |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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