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P-gp inhibitor 13

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Catalog No. T78974

P-gp Inhibitor 13, a P-glycoprotein antagonist, can counteract paclitaxel resistance in A2780/T cells, proving valuable for advanced acute myeloid leukemia research [1].

P-gp inhibitor 13

P-gp inhibitor 13

😃Good
Catalog No. T78974
P-gp Inhibitor 13, a P-glycoprotein antagonist, can counteract paclitaxel resistance in A2780/T cells, proving valuable for advanced acute myeloid leukemia research [1].
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Product Introduction

Bioactivity
Description
P-gp Inhibitor 13, a P-glycoprotein antagonist, can counteract paclitaxel resistance in A2780/T cells, proving valuable for advanced acute myeloid leukemia research [1].
In vitro
P-gp inhibitor 13 (Compound 27f) significantly chemosensitized A2780/T cells with an IC50 of 0.010 μM [1], increased paclitaxel and rhodamine 123 accumulation by inhibiting P-gp to reverse multidrug resistance (MDR) [1], exhibited minimal cardiotoxicity [1], and showed concentration-dependent MDR reversal at 2.5, 5, 10, and 20 μM in A2780/T cells [1].
Chemical Properties
Molecular Weight546.61
FormulaC32H34O8
Storage & Solubility Information
StorageShipping with blue ice.

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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