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PARP/EZH2-IN-1

Catalog No. T40310 CAS 2687273-52-3

PARP/EZH2-IN-1 is a novel compound that functions as a dual inhibitor for both PARP (IC50 6.87 nM) and EZH2 (IC50 36.51 nM), showing promising potential for the treatment of triple-negative breast cancer with wild-type BRCA.

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PARP/EZH2-IN-1, CAS 2687273-52-3

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	PARP/EZH2-IN-1 is a novel compound that functions as a dual inhibitor for both PARP (IC50 6.87 nM) and EZH2 (IC50 36.51 nM), showing promising potential for the treatment of triple-negative breast cancer with wild-type BRCA.
Targets&IC50	PARP-1:6.87 nM (IC50), EZH2:36.51 nM (IC50)

Molecular Weight	768.85
Formula	C43H41FN8O5
CAS No.	2687273-52-3

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Wang C, et al. Discovery of First-in-Class Dual PARP and EZH2 Inhibitors for Triple-Negative Breast Cancer with Wild-Type BRCA. J Med Chem. 2021 Sep 9;64(17):12630-12650.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

PARP/EZH2-IN-1 2687273-52-3 PARP/EZH2 IN 1 PARP/EZH-2-IN-1 PARP/EZH2IN1 Inhibitor inhibitor inhibit

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