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Pasireotide ditrifluoroacetate

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Catalog No. T13811
Alias SOM230 ditrifluoroacetate, Pasireotide TFA salt, Pasireotide ditrifluoroacetate (396091-73-9 free base)

Pasireotide is a stable cyclohexapeptide somatostatin mimic.

Pasireotide ditrifluoroacetate

Pasireotide ditrifluoroacetate

😃Good
Catalog No. T13811Alias SOM230 ditrifluoroacetate, Pasireotide TFA salt, Pasireotide ditrifluoroacetate (396091-73-9 free base)
Pasireotide is a stable cyclohexapeptide somatostatin mimic.
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1 mg165 €Backorder
5 mg544 €Backorder
10 mg867 €Backorder
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Product Introduction

Bioactivity
Description
Pasireotide is a stable cyclohexapeptide somatostatin mimic.
Targets&IC50
SST3:9.1(pki), SST1:pki:8.2 , SST5:9.9(pki), SST4:<7.0 (pki), SST2:9 (pki)
In vitro
SOM230, a novel, stable cyclohexapeptide somatostatin mimic that exhibits unique high-affinity binding to human somatostatin receptors (subtypes sst1-sst5).?SOM230 has potent, long-lasting inhibitory effects on growth hormone and insulin-like growth factor-1 release[1]
In vivo
Untreated SSTR2(-/-) mice with AIA displayed joint swelling and mechanical hyperalgesia similar to that seen in SSTR2(+/+) mice.?In wild-type mice, both octreotide and pasireotide significantly attenuated knee joint swelling and histopathologic manifestations of arthritis to an extent comparable to that of dexamethasone.?In SSTR2(-/-) mice, the antiinflammatory effects of both octreotide and pasireotide were completely abrogated.?Prolonged administration of pasireotide also inhibited joint swelling and protected against joint destruction during AIA flare reactions.?In addition, both octreotide and pasireotide reduced inflammatory hyperalgesia.?The antinociceptive actions of octreotide were abolished in SSTR2(-/-) mice, but those of pasireotide were retained.?In dorsal root ganglia of naive wild-type mice, only SSTR1 and SSTR2A, but not SSTR3 or SSTR5, were detected in a subset of small- and medium-diameter neurons[1].
AliasSOM230 ditrifluoroacetate, Pasireotide TFA salt, Pasireotide ditrifluoroacetate (396091-73-9 free base)
Chemical Properties
Molecular Weight1275.25
FormulaC62H68F6N10O13
Relative Density.1.31g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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