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PD 404182 is a human dimethylarginine dimethylaminohydrolase 1 (DDAH1) inhibitor with anti-angiogenic and antiviral activities, and can be used to study cardiovascular diseases and viral infections.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $32 | In Stock | |
5 mg | $75 | 7-10 days | |
10 mg | $113 | 7-10 days | |
25 mg | $228 | 7-10 days | |
50 mg | $372 | 7-10 days | |
100 mg | $548 | 7-10 days | |
1 mL x 10 mM (in DMSO) | $80 | 7-10 days |
Description | PD 404182 is a human dimethylarginine dimethylaminohydrolase 1 (DDAH1) inhibitor with anti-angiogenic and antiviral activities, and can be used to study cardiovascular diseases and viral infections. |
Targets&IC50 | HIV-1 (92UG029):1.18 μM, DDAH1 (human):9 μM, HIV-1 (96USNG31):0.14 μM, PBMC (human):200 μM (CC50) |
In vitro | The enzymatic activity of human DDAH1 was significantly and dose-dependently inhibited by PD 404182, with an IC50 = 9 μM. [1] PD 404182 exhibited antiviral activity toward all the viral isolates tested, with an average IC50 of 0.55 μM (IC50 range, 0.14 μM with HIV-1 96USNG31 to 1.18 μM with HIV-1 92UG029). A 48% reduction in cell viability was observed at the highest tested PD 404182 concentration (200 μM), resulting in a CC50 of ∼200 μM, indicating that PD 404182 is relatively nontoxic to freshly activated human PBMCs. [2] |
Alias | PD-404182, PD404182 |
Molecular Weight | 217.29 |
Formula | C11H11N3S |
Cas No. | 72596-74-8 |
Smiles | N=C1SC=2C=CC=CC2C3=NCCCN13 |
Relative Density. | 1.43 g/cm3 (Predicted) |
Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 40 mg/mL (184.09 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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