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PD 404182

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Catalog No. T28348Cas No. 72596-74-8
Alias PD-404182, PD404182

PD 404182 is a human dimethylarginine dimethylaminohydrolase 1 (DDAH1) inhibitor with anti-angiogenic and antiviral activities, and can be used to study cardiovascular diseases and viral infections.

PD 404182

PD 404182

😃Good
Purity: 99.20%
Catalog No. T28348Alias PD-404182, PD404182Cas No. 72596-74-8
PD 404182 is a human dimethylarginine dimethylaminohydrolase 1 (DDAH1) inhibitor with anti-angiogenic and antiviral activities, and can be used to study cardiovascular diseases and viral infections.
Pack SizePriceAvailabilityQuantity
1 mg$32 In Stock
5 mg$75 7-10 days
10 mg$113 7-10 days
25 mg$228 7-10 days
50 mg$372 7-10 days
100 mg$548 7-10 days
1 mL x 10 mM (in DMSO)$80 7-10 days
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Purity:99.20%
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Product Introduction

Bioactivity
Description
PD 404182 is a human dimethylarginine dimethylaminohydrolase 1 (DDAH1) inhibitor with anti-angiogenic and antiviral activities, and can be used to study cardiovascular diseases and viral infections.
Targets&IC50
HIV-1 (92UG029):1.18 μM, DDAH1 (human):9 μM, HIV-1 (96USNG31):0.14 μM, PBMC (human):200 μM (CC50)
In vitro
The enzymatic activity of human DDAH1 was significantly and dose-dependently inhibited by PD 404182, with an IC50 = 9 μM. [1]
PD 404182 exhibited antiviral activity toward all the viral isolates tested, with an average IC50 of 0.55 μM (IC50 range, 0.14 μM with HIV-1 96USNG31 to 1.18 μM with HIV-1 92UG029). A 48% reduction in cell viability was observed at the highest tested PD 404182 concentration (200 μM), resulting in a CC50 of ∼200 μM, indicating that PD 404182 is relatively nontoxic to freshly activated human PBMCs. [2]
AliasPD-404182, PD404182
Chemical Properties
Molecular Weight217.29
FormulaC11H11N3S
Cas No.72596-74-8
SmilesN=C1SC=2C=CC=CC2C3=NCCCN13
Relative Density.1.43 g/cm3 (Predicted)
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 40 mg/mL (184.09 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM4.6021 mL23.0107 mL46.0214 mL230.1072 mL
5 mM0.9204 mL4.6021 mL9.2043 mL46.0214 mL
10 mM0.4602 mL2.3011 mL4.6021 mL23.0107 mL
20 mM0.2301 mL1.1505 mL2.3011 mL11.5054 mL
50 mM0.0920 mL0.4602 mL0.9204 mL4.6021 mL
100 mM0.0460 mL0.2301 mL0.4602 mL2.3011 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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