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PD-1/PD-L1-IN-14

Catalog No. T61929Cas No. 2499965-12-5

PD-1/PD-L1-IN-14 (compound 17) is an inhibitor of PD-1/PD-L1 interaction (IC50=27.8 nM) that promotes PD-L1 dimerization, endocytosis, and degradation.

PD-1/PD-L1-IN-14

PD-1/PD-L1-IN-14

Catalog No. T61929Cas No. 2499965-12-5
PD-1/PD-L1-IN-14 (compound 17) is an inhibitor of PD-1/PD-L1 interaction (IC50=27.8 nM) that promotes PD-L1 dimerization, endocytosis, and degradation.
Pack SizePriceAvailabilityQuantity
25 mg$1,5206-8 weeks
50 mg$1,9806-8 weeks
100 mg$2,5006-8 weeks
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Product Introduction

Bioactivity
Description
PD-1/PD-L1-IN-14 (compound 17) is an inhibitor of PD-1/PD-L1 interaction (IC50=27.8 nM) that promotes PD-L1 dimerization, endocytosis, and degradation.
In vitro
Compound 17 (PD-1/PD-L1-IN-14) facilitates the internalization of PD-L1 from the cell surface into the cytosol and triggers its degradation in tumor cells via a lysosome-dependent pathway [1].
Chemical Properties
Molecular Weight400.47
FormulaC24H24N4O2
Cas No.2499965-12-5
Storage & Solubility Information
StorageShipping with blue ice.

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