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PDE1-IN-8 (Compound 3f) acts as an inhibitor of PDE1, with an IC50 of 11 nM. It hinders cAMP and cGMP signaling pathways, impeding the differentiation and proliferation of cells into myofibroblasts, and demonstrates antifibrotic effects in the Bleomycin-induced rat model of pulmonary fibrosis.
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50 mg | Inquiry | Backorder |
Description | PDE1-IN-8 (Compound 3f) acts as an inhibitor of PDE1, with an IC50 of 11 nM. It hinders cAMP and cGMP signaling pathways, impeding the differentiation and proliferation of cells into myofibroblasts, and demonstrates antifibrotic effects in the Bleomycin-induced rat model of pulmonary fibrosis. |
Targets&IC50 | PDE7A:2093 nM, PDE2A:1820 nM, PDE8A:3729 nM, PDE10A:2394 nM, PDE1C:11 nM, PDE3A:5164 nM, PDE4D:3006 nM, PDE5A:681 nM, PDE1A:263 nM, PDE1B:357 nM, PDE9A:4617 nM |
Molecular Weight | 408.32 |
Formula | C17H11Cl2N3OS2 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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