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Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $996 | Backorder | |
10 mg | $1,690 | Backorder |
Description | PDE12-IN-1 is a powerful and specific inhibitor of PDE12, exhibiting a pIC 50 value of 9.1 for enzyme inhibition. It effectively enhances levels of 2′,5′-linked adenylate polymers (2-5A), with a pEC 50 value of 7.7. Additionally, PDE12-IN-1 demonstrates antiviral activity. |
In vitro | PDE12-IN-1 effectively mitigates the cytopathic effect induced by EMCV in HeLa Ohio cells, demonstrating a potency with a pIC50 of 6.7. Additionally, it suppresses the proliferation of these cells independently of EMCV infection, showing a pIC50 of 5.7. This compound also hampers the growth of both HeLa and HeLaΔPDE12 cells, maintaining the same level of potency (pIC50 of 5.7). Moreover, PDE12-IN-1 showcases its antiviral activity by inhibiting HRV infection with a pIC50 of 6.9[1]. |
Alias | PDE12-IN-1 |
Molecular Weight | 616.491 |
Formula | C31H27BrFN5O3 |
Cas No. | 2259620-80-7 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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