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PDE2/PDE10-IN-1

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Catalog No. T12393Cas No. 1426833-08-0

PDE2/PDE10-IN-1 is an inhibitor of phosphodiesterase 2 (PDE2) and PDE10, with IC50 values of 29 nM and 480 nM, respectively.

PDE2/PDE10-IN-1

PDE2/PDE10-IN-1

😃Good
Catalog No. T12393Cas No. 1426833-08-0
PDE2/PDE10-IN-1 is an inhibitor of phosphodiesterase 2 (PDE2) and PDE10, with IC50 values of 29 nM and 480 nM, respectively.
Pack SizePriceAvailabilityQuantity
25 mg$1,4506-8 weeks
50 mg$1,8906-8 weeks
100 mg$2,5006-8 weeks
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Product Introduction

Bioactivity
Description
PDE2/PDE10-IN-1 is an inhibitor of phosphodiesterase 2 (PDE2) and PDE10, with IC50 values of 29 nM and 480 nM, respectively.
Targets&IC50
PDE11A (human):6920 nM, PDE2A (human):29 nM, PDE4D (human):5890 nM, PDE10A (rat):480 nM
In vitro
PDE2/PDE10-IN-1 inhibits PDE2 and PDE10(IC50 of 29 and 480 nM, respectively). PDE2/PDE10-IN-1 is also inactive up to a concentration of 125 μg/mL in a bacterial mutagenicity assay. PDE2/PDE10-IN-1 also inhibits PDE11A and PDE4D with IC50s of 6920 nM and 5890 nM, respectively. In addition PDE2/PDE10-IN-1 does not show significant inhibition of a panel of CYP450 enzymes (CYP1A2, 2C9, 2D6, 2C19, and 3A4).
In vivo
PDE2/PDE10-IN-1, which is orally bioavailable, occupies PDE2 with an ED50 of 21 mg/kg.
Chemical Properties
Molecular Weight295.73
FormulaC15H10ClN5
Cas No.1426833-08-0
Relative Density.1.49 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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