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Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $1,450 | 6-8 weeks | |
50 mg | $1,890 | 6-8 weeks | |
100 mg | $2,500 | 6-8 weeks |
Description | PDE2/PDE10-IN-1 is a inhibitor of phosphodiesterase 2 (PDE2) and PDE10(IC50s of 29 and 480 nM, respectively). |
In vitro | PDE2/PDE10-IN-1 inhibits PDE2 and PDE10(IC50 of 29 and 480 nM, respectively). PDE2/PDE10-IN-1 is also inactive up to a concentration of 125 μg/mL in a bacterial mutagenicity assay. PDE2/PDE10-IN-1 also inhibits PDE11A and PDE4D with IC50s of 6920 nM and 5890 nM, respectively. In addition PDE2/PDE10-IN-1 does not show significant inhibition of a panel of CYP450 enzymes (CYP1A2, 2C9, 2D6, 2C19, and 3A4). |
In vivo | PDE2/PDE10-IN-1, which is orally bioavailable, occupies PDE2 with an ED50 of 21 mg/kg. |
Molecular Weight | 295.73 |
Formula | C15H10ClN5 |
Cas No. | 1426833-08-0 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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